Nilotinib is associated with a reduced incidence of BCR-ABL mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase
Identifieur interne : 004575 ( Main/Exploration ); précédent : 004574; suivant : 004576Nilotinib is associated with a reduced incidence of BCR-ABL mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase
Auteurs : Andreas Hochhaus [Allemagne] ; Giuseppe Saglio [Italie] ; Richard A. Larson [États-Unis] ; Dong-Wook Kim [Corée du Sud] ; Gabriel Etienne [France] ; Gianantonio Rosti [Italie] ; Carmino De Souza [Brésil] ; Mineo Kurokawa [Japon] ; Matt E. Kalaycio [États-Unis] ; Albert Hoenekopp [Suisse] ; Xiaolin Fan [États-Unis] ; Yaping Shou [États-Unis] ; Hagop M. Kantarjian [États-Unis] ; Timothy P. Hughes [Australie]Source :
- Blood [ 0006-4971 ] ; 2013.
Abstract
Frontline nilotinib led to fewer, less diverse BCR-ABL mutations than imatinib in patients with chronic myeloid leukemia in chronic phase. Rates of progression to accelerated phase/blast crisis were lower with nilotinib than imatinib in patients with emergent BCR-ABL mutations.
Url:
DOI: 10.1182/blood-2012-04-423418
PubMed: 23502220
PubMed Central: 4915803
Affiliations:
- Allemagne, Australie, Brésil, Corée du Sud, France, Italie, Japon, Suisse, États-Unis
- Aquitaine, Illinois, New Jersey, Nouvelle-Aquitaine, Ohio, Région capitale de Séoul, Région de Kantō, Texas
- Bordeaux, Séoul, Tokyo
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Le document en format XML
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Seràgnoli, University of Bologna, Bologna, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute L. e A. Seràgnoli, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="De Souza, Carmino" sort="De Souza, Carmino" uniqKey="De Souza C" first="Carmino" last="De Souza">Carmino De Souza</name><affiliation wicri:level="1"><nlm:aff id="aff7">UNICAMP, University of Campinas-SP, Campinas, Brazil;</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>UNICAMP, University of Campinas-SP, Campinas</wicri:regionArea><wicri:noRegion>Campinas</wicri:noRegion></affiliation></author><author><name sortKey="Kurokawa, Mineo" sort="Kurokawa, Mineo" uniqKey="Kurokawa M" first="Mineo" last="Kurokawa">Mineo Kurokawa</name><affiliation wicri:level="3"><nlm:aff id="aff8">University of Tokyo Hospital, Tokyo, Japan;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>University of Tokyo Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><affiliation wicri:level="2"><nlm:aff id="aff9">Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Taussig Cancer Institute, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Hoenekopp, Albert" sort="Hoenekopp, Albert" uniqKey="Hoenekopp A" first="Albert" last="Hoenekopp">Albert Hoenekopp</name><affiliation wicri:level="1"><nlm:aff id="aff10">Novartis Pharma AG, Basel, Switzerland;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Novartis Pharma AG, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Xiaolin" sort="Fan, Xiaolin" uniqKey="Fan X" first="Xiaolin" last="Fan">Xiaolin Fan</name><affiliation wicri:level="2"><nlm:aff id="aff11">Novartis Pharmaceuticals Corporation, East Hanover, NJ;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:cityArea></affiliation></author><author><name sortKey="Shou, Yaping" sort="Shou, Yaping" uniqKey="Shou Y" first="Yaping" last="Shou">Yaping Shou</name><affiliation wicri:level="2"><nlm:aff id="aff11">Novartis Pharmaceuticals Corporation, East Hanover, NJ;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:cityArea></affiliation></author><author><name sortKey="Kantarjian, Hagop M" sort="Kantarjian, Hagop M" uniqKey="Kantarjian H" first="Hagop M." last="Kantarjian">Hagop M. Kantarjian</name><affiliation wicri:level="2"><nlm:aff wicri:cut="; and" id="aff12">MD Anderson Cancer Center, University of Texas, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>MD Anderson Cancer Center, University of Texas, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Hughes, Timothy P" sort="Hughes, Timothy P" uniqKey="Hughes T" first="Timothy P." last="Hughes">Timothy P. Hughes</name><affiliation wicri:level="1"><nlm:aff id="aff13">Centre for Cancer Biology, SA Pathology, University of Adelaide, Adelaide, SA, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Cancer Biology, SA Pathology, University of Adelaide, Adelaide, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>Frontline nilotinib led to fewer, less diverse BCR-ABL mutations than imatinib in patients with chronic myeloid leukemia in chronic phase.</p></list-item><list-item><p>Rates of progression to accelerated phase/blast crisis were lower with nilotinib than imatinib in patients with emergent BCR-ABL mutations.</p></list-item></list></p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Brésil</li><li>Corée du Sud</li><li>France</li><li>Italie</li><li>Japon</li><li>Suisse</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Illinois</li><li>New Jersey</li><li>Nouvelle-Aquitaine</li><li>Ohio</li><li>Région capitale de Séoul</li><li>Région de Kantō</li><li>Texas</li></region><settlement><li>Bordeaux</li><li>Séoul</li><li>Tokyo</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Hochhaus, Andreas" sort="Hochhaus, Andreas" uniqKey="Hochhaus A" first="Andreas" last="Hochhaus">Andreas Hochhaus</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Saglio, Giuseppe" sort="Saglio, Giuseppe" uniqKey="Saglio G" first="Giuseppe" last="Saglio">Giuseppe Saglio</name></noRegion><name sortKey="Rosti, Gianantonio" sort="Rosti, Gianantonio" uniqKey="Rosti G" first="Gianantonio" last="Rosti">Gianantonio Rosti</name></country><country name="États-Unis"><region name="Illinois"><name sortKey="Larson, Richard A" sort="Larson, Richard A" uniqKey="Larson R" first="Richard A." last="Larson">Richard A. Larson</name></region><name sortKey="Fan, Xiaolin" sort="Fan, Xiaolin" uniqKey="Fan X" first="Xiaolin" last="Fan">Xiaolin Fan</name><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><name sortKey="Kantarjian, Hagop M" sort="Kantarjian, Hagop M" uniqKey="Kantarjian H" first="Hagop M." last="Kantarjian">Hagop M. 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